KYNU Back

kynureninase (L-kynurenine hydrolase)

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NCBI Description of KYNU
Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants.

Community Annotation of KYNU Add / Edit KYNU: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

KYNU is highly significantly mutated in
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KYNU is significantly mutated in
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KYNU is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for KYNU