KRT2 Back

keratin 2 (epidermal ichthyosis bullosa of Siemens)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of KRT2
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

Community Annotation of KRT2 Add / Edit KRT2: Annotations

No community annotations yet for KRT2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

KRT2 is highly significantly mutated in
(none)
KRT2 is significantly mutated in
(none)
KRT2 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for KRT2