KRT10 Back

keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris)

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NCBI Description of KRT10
This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21.

Community Annotation of KRT10 Add / Edit KRT10: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

KRT10 is highly significantly mutated in
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KRT10 is significantly mutated in
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KRT10 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for KRT10