KNG1 Back

kininogen 1

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NCBI Description of KNG1
This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.

Community Annotation of KNG1 Add / Edit KNG1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

KNG1 is highly significantly mutated in
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KNG1 is significantly mutated in
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KNG1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for KNG1