KLHL13 Back

kelch-like 13 (Drosophila)

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NCBI Description of KLHL13
This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants.

Community Annotation of KLHL13 Add / Edit KLHL13: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

KLHL13 is highly significantly mutated in
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KLHL13 is significantly mutated in
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KLHL13 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for KLHL13