KLF14 Back

Kruppel-like factor 14

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NCBI Description of KLF14

This gene encodes a member of the Kruppel-like family of transcription factors. The gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. Expression of this gene is induced by TGF-beta, and the protein represses TGF-beta receptor II expression. The protein functions as part of a transcriptional co-repressor complex that also contains the transcriptional regulator SIN3A and histone deacetylase 2.

Community Annotation of KLF14 Add / Edit KLF14: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


KLF14 is highly significantly mutated in
KLF14 is significantly mutated in
KLF14 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for KLF14