KIF7 Back

kinesin family member 7

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NCBI Description of KIF7
This gene encodes a cilia-associated protein belonging to the kinesin family. This protein plays a role in the sonic hedgehog (SHH) signaling pathway through the regulation of GLI transcription factors. It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand, and as a positive regulator by preventing the processing of GLI3 into its repressor form. Mutations in this gene have been associated with various ciliopathies.

Community Annotation of KIF7 Add / Edit KIF7: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

KIF7 is highly significantly mutated in
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KIF7 is significantly mutated in
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KIF7 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for KIF7