KDM5A Back

lysine (K)-specific demethylase 5A

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NCBI Description of KDM5A
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein which regulates cell proliferation. This protein also interacts with rhombotin-2 which functions distinctly in erythropoiesis and in T-cell leukemogenesis. Rhombotin-2 is thought to either directly affect the activity of the encoded protein or may indirectly modulate the functions of the retinoblastoma protein by binding to this protein. ##RefSeq-Attributes-START## Transcript_exon_combination_evidence :: AB209999.1 [ECO:0000332] ##RefSeq-Attributes-END##

Community Annotation of KDM5A Add / Edit KDM5A: Annotations

No community annotations yet for KDM5A.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

KDM5A is highly significantly mutated in
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KDM5A is significantly mutated in
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KDM5A is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for KDM5A