KDM4A Back

lysine (K)-specific demethylase 4A

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NCBI Description of KDM4A
This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.

Community Annotation of KDM4A Add / Edit KDM4A: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

KDM4A is highly significantly mutated in
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KDM4A is significantly mutated in
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KDM4A is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for KDM4A