KCNQ5 Back

potassium voltage-gated channel, KQT-like subfamily, member 5

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NCBI Description of KCNQ5
This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

KCNQ5 is highly significantly mutated in
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KCNQ5 is significantly mutated in
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KCNQ5 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for KCNQ5