KCNQ4 Back

potassium voltage-gated channel, KQT-like subfamily, member 4

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NCBI Description of KCNQ4
The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of KCNQ4 Add / Edit KCNQ4: Annotations

No community annotations yet for KCNQ4.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

KCNQ4 is highly significantly mutated in
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KCNQ4 is significantly mutated in
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KCNQ4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for KCNQ4