KCNMB4 Back

potassium large conductance calcium-activated channel, subfamily M, beta member 4

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NCBI Description of KCNMB4
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

Community Annotation of KCNMB4 Add / Edit KCNMB4: Annotations

No community annotations yet for KCNMB4.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

KCNMB4 is highly significantly mutated in
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KCNMB4 is significantly mutated in
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KCNMB4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for KCNMB4