potassium large conductance calcium-activated channel, subfamily M, beta member 2

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NCBI Description of KCNMB2

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Two variants encoding the same protein have been found for this gene.

Community Annotation of KCNMB2 Add / Edit KCNMB2: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


KCNMB2 is highly significantly mutated in
KCNMB2 is significantly mutated in
KCNMB2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for KCNMB2