KCNJ10 Back

potassium inwardly-rectifying channel, subfamily J, member 10

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NCBI Description of KCNJ10
This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

Community Annotation of KCNJ10 Add / Edit KCNJ10: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

KCNJ10 is highly significantly mutated in
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KCNJ10 is significantly mutated in
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KCNJ10 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for KCNJ10