KCNIP2 Back

Kv channel interacting protein 2

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NCBI Description of KCNIP2
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene.

Community Annotation of KCNIP2 Add / Edit KCNIP2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

KCNIP2 is highly significantly mutated in
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KCNIP2 is significantly mutated in
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KCNIP2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for KCNIP2