KCNIP1 Back

Kv channel interacting protein 1

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NCBI Description of KCNIP1
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.

Community Annotation of KCNIP1 Add / Edit KCNIP1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

KCNIP1 is highly significantly mutated in
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KCNIP1 is significantly mutated in
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KCNIP1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for KCNIP1