KCNE3 Back

potassium voltage-gated channel, Isk-related family, member 3

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of KCNE3
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. A missense mutation in this gene is associated with hypokalemic periodic paralysis.

Community Annotation of KCNE3 Add / Edit KCNE3: Annotations

No community annotations yet for KCNE3.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

KCNE3 is highly significantly mutated in
(none)
KCNE3 is significantly mutated in
(none)
KCNE3 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for KCNE3