KBTBD13 Back

kelch repeat and BTB (POZ) domain containing 13

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NCBI Description of KBTBD13
The gene belongs to a family of genes encoding proteins containing a BTB domain and several kelch repeats. The BTB domain functions as a protein-protein interaction module, which includes an ability to self-associate or to interact with non-BTB domain-containing proteins. The kelch motif typically occurs in groups of five to seven repeats, and has been found in proteins with diverse functions. Known functions of these family members include transcription regulation, ion channel tetramerization and gating, protein ubiquitination or degradation, and cytoskeleton regulation. The exact function of this family member has yet to be determined. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. There are no full-length transcripts representing this locus in human; the extent of this transcript is supported by partial human transcript alignments and by aligning homologous transcripts from mouse GeneID:74492.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

KBTBD13 is highly significantly mutated in
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KBTBD13 is significantly mutated in
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KBTBD13 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for KBTBD13