JRK Back

jerky homolog (mouse)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of JRK
This gene is the human homolog of the mouse jerky gene. The encoded protein has similarity to several nuclear regulatory proteins, including centromere protein B, suggesting that it might function as a DNA-binding protein. Insertional inactivation of this gene in transgenic mice resulted in epileptic seizures. Childhood Absence Epilepsy (CAE) has been mapped to the same chromosomal location (8q24.3) as this gene, making this gene a strong candidate for CAE. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of JRK Add / Edit JRK: Annotations

No community annotations yet for JRK.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

JRK is highly significantly mutated in
(none)
JRK is significantly mutated in
(none)
JRK is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for JRK