JAM2 Back

junctional adhesion molecule 2

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NCBI Description of JAM2
This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene.

Community Annotation of JAM2 Add / Edit JAM2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

JAM2 is highly significantly mutated in
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JAM2 is significantly mutated in
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JAM2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for JAM2