IVD Back

isovaleryl Coenzyme A dehydrogenase

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NCBI Description of IVD
Isovaleryl-CoA dehydrogenase (IVD) is a mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism. The genetic deficiency of IVD results in an accumulation of isovaleric acid, which is toxic to the central nervous system and leads to isovaleric acidemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Community Annotation of IVD Add / Edit IVD: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

IVD is highly significantly mutated in
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IVD is significantly mutated in
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IVD is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for IVD