ITSN2 Back

intersectin 2

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NCBI Description of ITSN2
This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. Alternatively spliced transcript variants have been found for this gene that encode three distinct isoforms. Additional variants have been found but their full length nature has not been determined.

Community Annotation of ITSN2 Add / Edit ITSN2: Annotations

No community annotations yet for ITSN2.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ITSN2 is highly significantly mutated in
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ITSN2 is significantly mutated in
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ITSN2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ITSN2