ITPR3 Back

inositol 1,4,5-triphosphate receptor, type 3

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NCBI Description of ITPR3

This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


ITPR3 is highly significantly mutated in
ITPR3 is significantly mutated in
ITPR3 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for ITPR3