ITIH4 Back

inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)

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NCBI Description of ITIH4
The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of ITIH4 Add / Edit ITIH4: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ITIH4 is highly significantly mutated in
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ITIH4 is significantly mutated in
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ITIH4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ITIH4