ITIH3 Back

inter-alpha (globulin) inhibitor H3

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ITIH3

The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).[supplied by OMIM, Nov 2009].

Community Annotation of ITIH3 Add / Edit ITIH3: Annotations

No community annotations yet for ITIH3.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ITIH3 is highly significantly mutated in
(none)
ITIH3 is significantly mutated in
(none)
ITIH3 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for ITIH3