ITIH2 Back

inter-alpha (globulin) inhibitor H2

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ITIH2

The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).[supplied by OMIM, Nov 2009].

Community Annotation of ITIH2 Add / Edit ITIH2: Annotations

No community annotations yet for ITIH2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


ITIH2 is highly significantly mutated in
ITIH2 is significantly mutated in
ITIH2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for ITIH2