ITGB8 Back

integrin, beta 8

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ITGB8
This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Community Annotation of ITGB8 Add / Edit ITGB8: Annotations

No community annotations yet for ITGB8.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ITGB8 is highly significantly mutated in
(none)
ITGB8 is significantly mutated in
(none)
ITGB8 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ITGB8