ITGAX Back

integrin, alpha X (complement component 3 receptor 4 subunit)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ITGAX
This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles.

Community Annotation of ITGAX Add / Edit ITGAX: Annotations

No community annotations yet for ITGAX.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ITGAX is highly significantly mutated in
(none)
ITGAX is significantly mutated in
(none)
ITGAX is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ITGAX