ITGAE Back

integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)

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NCBI Description of ITGAE
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ITGAE is highly significantly mutated in
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ITGAE is significantly mutated in
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ITGAE is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ITGAE