ITGA5 Back

integrin, alpha 5 (fibronectin receptor, alpha polypeptide)

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NCBI Description of ITGA5

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ITGA5 is highly significantly mutated in
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ITGA5 is significantly mutated in
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ITGA5 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for ITGA5