ITGA2B Back

integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)

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NCBI Description of ITGA2B
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ITGA2B is highly significantly mutated in
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ITGA2B is significantly mutated in
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ITGA2B is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ITGA2B