ITGA2 Back

integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)

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NCBI Description of ITGA2
This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ITGA2 is highly significantly mutated in
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ITGA2 is significantly mutated in
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ITGA2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ITGA2