ITGA1 Back

integrin, alpha 1

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NCBI Description of ITGA1
This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding.

Community Annotation of ITGA1 Add / Edit ITGA1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ITGA1 is highly significantly mutated in
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ITGA1 is significantly mutated in
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ITGA1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ITGA1