ISL1 Back

ISL LIM homeobox 1

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NCBI Description of ISL1
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.

Community Annotation of ISL1 Add / Edit ISL1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ISL1 is highly significantly mutated in
(none)
ISL1 is significantly mutated in
(none)
ISL1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ISL1