ISCU Back

iron-sulfur cluster scaffold homolog (E. coli)

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NCBI Description of ISCU
Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors, chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria.

Community Annotation of ISCU Add / Edit ISCU: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ISCU is highly significantly mutated in
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ISCU is significantly mutated in
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ISCU is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ISCU