IRX1 Back

iroquois homeobox 1

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NCBI Description of IRX1

This gene encodes a member of the Iroquois homeobox protein family. Homeobox genes in this family are involved in pattern formation in the embryo. The gene product has been identified as a tumor suppressor in gastric (PMID: 21602894, 20440264) and head and neck cancers (PMID: 18559491). A pseudogene of this gene is located on chromosome 13.

Community Annotation of IRX1 Add / Edit IRX1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


IRX1 is highly significantly mutated in
IRX1 is significantly mutated in
IRX1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for IRX1