IRS4 Back

insulin receptor substrate 4

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of IRS4
IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation..

Community Annotation of IRS4 Add / Edit IRS4: Annotations

No community annotations yet for IRS4.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

IRS4 is highly significantly mutated in
(none)
IRS4 is significantly mutated in
(none)
IRS4 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for IRS4