IRS1 Back

insulin receptor substrate 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of IRS1

This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data.

Community Annotation of IRS1 Add / Edit IRS1: Annotations

No community annotations yet for IRS1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


IRS1 is highly significantly mutated in
IRS1 is significantly mutated in
IRS1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for IRS1