IRF3 Back

interferon regulatory factor 3

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NCBI Description of IRF3

This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Community Annotation of IRF3 Add / Edit IRF3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

IRF3 is highly significantly mutated in
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IRF3 is significantly mutated in
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IRF3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for IRF3