IRF2 Back

interferon regulatory factor 2

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NCBI Description of IRF2

IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


IRF2 is highly significantly mutated in
IRF2 is significantly mutated in
IRF2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for IRF2