IRAK3 Back

interleukin-1 receptor-associated kinase 3

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NCBI Description of IRAK3
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants.

Community Annotation of IRAK3 Add / Edit IRAK3: Annotations

No community annotations yet for IRAK3.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

IRAK3 is highly significantly mutated in
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IRAK3 is significantly mutated in
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IRAK3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for IRAK3