INTS6 Back

integrator complex subunit 6

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NCBI Description of INTS6
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene.

Community Annotation of INTS6 Add / Edit INTS6: Annotations

No community annotations yet for INTS6.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

INTS6 is highly significantly mutated in
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INTS6 is significantly mutated in
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INTS6 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for INTS6