INSL3 Back

insulin-like 3 (Leydig cell)

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NCBI Description of INSL3
This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants.

Community Annotation of INSL3 Add / Edit INSL3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

INSL3 is highly significantly mutated in
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INSL3 is significantly mutated in
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INSL3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for INSL3