insulin induced gene 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of INSIG1

Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Community Annotation of INSIG1 Add / Edit INSIG1: Annotations

No community annotations yet for INSIG1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


INSIG1 is highly significantly mutated in
INSIG1 is significantly mutated in
INSIG1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for INSIG1