INSC Back

inscuteable homolog (Drosophila)

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NCBI Description of INSC
In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar 2008].

Community Annotation of INSC Add / Edit INSC: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

INSC is highly significantly mutated in
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INSC is significantly mutated in
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INSC is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for INSC