inositol polyphosphate-5-phosphatase F

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NCBI Description of INPP5F

The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Community Annotation of INPP5F Add / Edit INPP5F: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


INPP5F is highly significantly mutated in
INPP5F is significantly mutated in
INPP5F is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for INPP5F