IMP (inosine monophosphate) dehydrogenase 2

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NCBI Description of IMPDH2

This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.

Community Annotation of IMPDH2 Add / Edit IMPDH2: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


IMPDH2 is highly significantly mutated in
IMPDH2 is significantly mutated in
IMPDH2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for IMPDH2