IL2RG Back

interleukin 2 receptor, gamma (severe combined immunodeficiency)

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NCBI Description of IL2RG
The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder.

Community Annotation of IL2RG Add / Edit IL2RG: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

IL2RG is highly significantly mutated in
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IL2RG is significantly mutated in
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IL2RG is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for IL2RG