IL28RA Back

interleukin 28 receptor, alpha (interferon, lambda receptor)

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NCBI Description of IL28RA
The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.

Community Annotation of IL28RA Add / Edit IL28RA: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

IL28RA is highly significantly mutated in
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IL28RA is significantly mutated in
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IL28RA is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for IL28RA