IL18BP Back

interleukin 18 binding protein

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NCBI Description of IL18BP
The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Community Annotation of IL18BP Add / Edit IL18BP: Annotations

No community annotations yet for IL18BP.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

IL18BP is highly significantly mutated in
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IL18BP is significantly mutated in
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IL18BP is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for IL18BP